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Molecular and epidemiologic analysis of enterovirus B neurological infection in Argentine children

Alicia Susana Mistchenko1, Mariana Viegas, Maria Paula Della Latta

  • 1Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, Virology Laboratory, Dr. Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|September 20, 2006
PubMed

Insights

Human enteroviruses (HEV) cause significant central nervous system (CNS) infections in children. This study found HEV responsible for 27% of pediatric CNS hospitalizations, with aseptic meningitis being the most common diagnosis.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Virology

Background:

  • Human enteroviruses (HEV) are a leading cause of central nervous system (CNS) infections in pediatric patients.
  • Understanding the epidemiology and specific serotypes of HEV is crucial for effective diagnosis and management of CNS infections in children.

Purpose of the Study:

  • To investigate the prevalence and etiological role of human enteroviruses (HEV) in pediatric central nervous system (CNS) infections.
  • To identify the clinical syndromes associated with HEV infections and determine the most common HEV serotypes.

Main Methods:

  • A retrospective study of 1242 children under 15 years old with suspected CNS infection from 1998 to 2003.
  • Cerebrospinal fluid (CSF) samples were analyzed using RT-PCR and VP1 gene sequencing for molecular typing of HEV.
  • Patients were categorized based on clinical syndromes, including aseptic meningitis, encephalitis, and febrile seizures.

Main Results:

  • Human enteroviruses (HEV) were detected in 26.97% (335/1242) of CSF samples.
  • HEV was most frequently associated with aseptic meningitis (72.5% of HEV cases), followed by febrile infants and neonatal infections.
  • Molecular serotyping identified Echovirus 30, Echovirus 9, Coxsackie B3-B5, and Echovirus 33 as the most prevalent HEV-B serotypes.

Conclusions:

  • Human enteroviruses (HEV) are a significant cause of central nervous system (CNS) compromise in hospitalized children, accounting for 27% of all etiologies.
  • The findings highlight the importance of HEV testing in pediatric CNS infections and provide insights into seasonal patterns and prevalent serotypes in Buenos Aires.
Abstract

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