Related Experiment Video
Updated: Jul 20, 2026
08:44
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
[Expression of eosinophil major basic protein mRNA in bronchial asthma]
Shuang-hong Li1, Ya-ling Luo, Wen-yan Lai
1Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. lsh0224@163.com
Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|September 20, 2006
Summary
Eosinophil major basic protein (MBP) mRNA levels are significantly elevated in asthma patients and correlate with disease severity and reduced lung function. This suggests MBP plays a key role in asthma development.
Area of Science:
- Respiratory Medicine
- Molecular Biology
- Immunology
Context:
- Bronchial asthma is a chronic inflammatory airway disease.
- Eosinophils are key inflammatory cells implicated in asthma pathogenesis.
- Major basic protein (MBP) is a primary granule protein of eosinophils.
Purpose:
- To investigate the expression levels of eosinophil major basic protein (MBP) mRNA in bronchial asthma.
- To explore the correlation between MBP mRNA levels and asthma severity.
- To analyze the association of MBP mRNA with eosinophil count and pulmonary function.
Summary:
- Semi-quantitative RT-PCR analysis revealed significantly higher MBP mRNA levels in asthma patients compared to healthy controls.
- MBP mRNA levels increased progressively with asthma severity (mild, moderate, severe).
- Asthma patients exhibited significantly elevated eosinophil counts and inverse correlation between MBP mRNA levels and pulmonary function.
Impact:
- Increased MBP mRNA expression correlates with asthma severity, indicating its role in disease progression.
- MBP may be a significant factor in the pathophysiology of bronchial asthma.
- These findings contribute to understanding the molecular mechanisms underlying asthma and may inform future therapeutic strategies.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:13Asthma III: Clinical Manifestations
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...