Related Experiment Video

Updated: Jul 20, 2026

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

Selectin polymorphisms and perinatal morbidity in low-birthweight infants

László Derzbach1, Géza Bokodi, András Treszl

  • 1First Department of Paediatrics, Semmelweis University, Budapest, Hungary. derla@gyer1.sote.hu

Acta Paediatrica (Oslo, Norway : 1992)
|September 20, 2006
PubMed

Insights

Functional polymorphisms in selectin genes were investigated for links to perinatal conditions. L-selectin gene variants, specifically the 213Ser allele, were more common in low-birthweight infants, suggesting a role in bronchopulmonary dysplasia.

Area of Science:

  • Perinatal medicine
  • Genetics
  • Immunology

Background:

  • Altered selectin expression is linked to premature birth, sepsis, and bronchopulmonary dysplasia.
  • Selectins play a role in inflammatory and immune responses during pregnancy and in neonates.

Purpose of the Study:

  • To investigate the association between functional polymorphisms in E-, P-, and L-selectin genes and perinatal morbidity.
  • To determine if specific selectin gene variants increase the risk of premature birth, sepsis, or bronchopulmonary dysplasia.

Main Methods:

  • Genotype distribution of E-selectin (Ser128Arg), P-selectin (Thr715Pro), and L-selectin (Pro213Ser) polymorphisms was compared between 125 low-birthweight infants and 156 healthy term neonates.
  • The association between these genotypes and the risk of sepsis and bronchopulmonary dysplasia was analyzed.

Main Results:

  • No association was found between E-selectin or P-selectin polymorphisms and premature birth, early sepsis, or bronchopulmonary dysplasia.
  • Carriers of the L-selectin 213Ser allele were more prevalent in low-birthweight infants, particularly those with bronchopulmonary dysplasia.
  • No association was observed between L-selectin polymorphism and early postnatal sepsis.

Conclusions:

  • L-selectin appears to play a significant role in perinatal pathology.
  • Further research is needed to understand the impact of L-selectin levels in 213Ser allele carriers on premature birth and bronchopulmonary dysplasia.
Abstract

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...