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Circulating adiponectin levels in Kawasaki disease
Seiichiro Takeshita1, Humiyo Takabayashi, Naoki Yoshida
1Junior College, University of Shizuoka, Shizuoka, Japan. takeshit@mx.ibaraki.ac.jp
Aim:
To investigate the kinetics of adipocytokine in Kawasaki disease (KD).
Methods:
The plasma levels of adiponectin, IL-6 and TNF-alpha were measured in 20 patients with KD, 15 patients with acute febrile diseases (disease control, DC) and 15 healthy children (HC).
Results:
Plasma adiponectin levels in patients with acute KD were significantly lower (p < 0.01) than those with convalescent KD, DC and HC. The decreased levels of adiponectin negatively correlated with the increased levels of CRP and IL-6 in acute KD.
Conclusion:
Hypoadiponectinaemia was shown during the acute phase of KD vasculitis. The downregulation of adiponectin secreted from adipose tissue may be closely linked to upregulation of systemic pro-inflammatory markers in acute KD.
