Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differences in vertebrate microRNA expression.

Brandon Ason1, Diana K Darnell, Beate Wittbrodt

  • 1Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.

Proceedings of the National Academy of Sciences of the United States of America
|September 20, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mice with humanized FXR ligand-binding domain display distinct metabolic responses upon pharmacological FXR stimulation.

Journal of lipid research·2026
Same author

Targeting the cell membrane in established and emerging model organisms.

Development (Cambridge, England)·2026
Same author

Bile Acid Detergency as Determinant of Liver Pathology in a Humanized Mouse Model of Progressive Familial Intrahepatic Cholestasis Type 3.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Targeting modulated vascular smooth muscle cells in atherosclerosis via FAP-directed immunotherapy.

Science (New York, N.Y.)·2026
Same author

Insights and emerging perspectives from the 2025 Medaka PI/ERC IndiGene meeting: Heidelberg July 22-24, 2025.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
See all related articles

MicroRNA (miRNA) expression timing and location are not strictly conserved across species. Differences in miRNA expression may contribute to physiological variations during animal development.

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression, influencing processes like cell proliferation and differentiation.
  • While miRNAs are conserved and predicted to regulate many transcripts, their expression patterns across species are not fully understood.
  • It was previously assumed that sequence conservation implied expression conservation.

Purpose of the Study:

  • To investigate the conservation of miRNA expression timing and location across different vertebrate species.
  • To explore the relationship between miRNA expression variation and physiological differences.

Main Methods:

  • Comparative analysis of approximately 100 miRNA expression profiles.
  • Comparison of expression data in medaka and chicken with existing data from zebrafish and mouse.

Related Experiment Videos

Main Results:

  • MiRNA expression timing and location are not strictly conserved between the studied species.
  • Differences in miRNA expression correlate with variations in miRNA copy number and genomic context.
  • Greater physiological differences between species were associated with more pronounced miRNA expression variation.

Conclusions:

  • The assumption of strict expression conservation for miRNAs based on sequence conservation is not supported.
  • Variations in miRNA expression likely play a role in the evolution of physiological differences during animal development.