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Updated: Jul 20, 2026

Cell Population Analyses During Skin Carcinogenesis
06:53

Cell Population Analyses During Skin Carcinogenesis

Published on: August 21, 2013

Cyclin D2 and cyclin D3 play opposite roles in mouse skin carcinogenesis

P Rojas1, M B Cadenas, P-C Lin

  • 1Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, TX, USA.

Oncogene
|September 20, 2006
PubMed

Insights

Cyclin D3 inhibits, while cyclin D2 promotes, skin tumor development in mice. Cyclin D3

Area of Science:

  • Cell Biology
  • Oncology
  • Molecular Biology

Background:

  • D-type cyclins regulate cell cycle progression, linking signaling pathways to G1 phase transition.
  • Previous studies examined cyclin D1, D2, and D3 overexpression in mouse skin and tumor development.

Purpose of the Study:

  • To investigate the roles of cyclin D2 and cyclin D3 in ras-dependent skin tumorigenesis.

Main Methods:

  • Overexpression of cyclin D3 and cyclin D2 in mouse skin models.
  • Analysis of tumor development, malignant progression to squamous cell carcinomas (SCC).
  • Biochemical analysis of keratinocytes and cyclin D2 kinase activity.
  • Genetic ablation and reinstatement of cyclin D2.

Main Results:

  • Cyclin D3 overexpression reduced tumor development and malignant progression to SCC.
  • Cyclin D3 overexpression led to decreased cyclin D2 levels and associated kinase activity.
  • Reinstatement of cyclin D2 reversed cyclin D3's inhibitory effects.
  • Cyclin D2 ablation reduced tumorigenesis and malignant progression.
  • Cyclin D2 overexpression increased papilloma formation and malignant progression.

Conclusions:

  • Cyclin D3 and cyclin D2 exhibit opposing roles in mouse skin tumor development.
  • Cyclin D3's tumor-suppressive activity is mediated by downregulation of cyclin D2.

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