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The effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis

Cheng Xiao1, Cheng Lu, Linhua Zhao

  • 1Institute of Basic Theory, China Academy of Traditional Chinese Medicine, Beijing, PR China.

Planta Medica
|September 20, 2006
PubMed

For investigating the effects of triptolide on enteric mucosal immune responses of DBA/1 mice with collagen-induced arthritis (CIA), the changes of the Peyer's patches, IEL (intraepithelial lymphocytes), LPL (lamina propria lymphocytes), periphery lymphocytes, and levels of TGF-beta in CIA mice were checked with flow cytometry or ELISA. Our results showed that triptolide could lower the arthritic scores and increase TGF-beta level. Triptolide also had an effect on enteric mucosal immune lymphocytes in Peyer's patch, IEL and LPL of CIA mice. The regulation of enteric mucosal lymphocytes might explain some of the immunosuppressive activities of triptolide.

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