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Updated: Jul 19, 2026
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Application of Laparoscopic Hepatectomy Combined with Intraoperative Microwave Ablation in Colorectal Cancer Liver Metastasis
Published on: March 3, 2023
Intraoperative triple antenna hepatic microwave ablation.
Caroline J Simon1, Damian E Dupuy, David A Iannitti
1Department of Diagnostic Imaging, Brown Medical School, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA.
AJR. American Journal of Roentgenology
|September 21, 2006
Summary
Synchronous triple antenna microwave ablation is a feasible intraoperative treatment for liver tumors before resection. This method effectively ablates hepatic malignancies, even near large vessels, with no viable tumor remaining in the ablation zone.
Area of Science:
- Oncology
- Surgical Oncology
- Interventional Radiology
Background:
- Microwave ablation (MWA) is an evolving minimally invasive treatment for unresectable hepatic malignancies.
- Hepatic resection remains a primary treatment for liver tumors, but not all patients are candidates.
- Synchronous MWA offers a potential neoadjuvant or alternative therapy for liver tumors.
Purpose of the Study:
- To evaluate the feasibility and preliminary outcomes of synchronous triple antenna MWA prior to elective hepatic resection in patients with hepatic masses.
- To assess the safety and efficacy of multi-antenna MWA in achieving complete tumor ablation.
Main Methods:
- A phase 1, two-center clinical trial involving ten patients with hepatic masses.
- Intraoperative MWA using three antennas in a triangular configuration at 45 W for 10 minutes, followed by standard hepatic resection.
- Histopathological analysis including H&E and NADH staining to evaluate tumor and ablation zone characteristics.
Main Results:
- Ten patients (mean age 64) with colorectal carcinoma metastases and hepatocellular carcinoma underwent the procedure.
- Mean tumor diameter was 4.4 cm; mean ablation diameter was 5.5 cm, with an average volume of 50.8 cm³.
- Histopathology confirmed complete coagulation necrosis and absence of viable tumor within the ablation zone, even surrounding large hepatic vessels.
Conclusions:
- Synchronous triple antenna MWA is a feasible intraoperative technique for treating liver tumors.
- The ablation zone demonstrated effective tumor destruction with safety margins around critical structures.
- Further percutaneous studies are warranted to explore MWA for nonsurgical candidates.
