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Updated: Jul 19, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Immune and genetic therapies for advanced renal cell carcinoma

A Zisman, A J Pantuck, A Belldegrun

    Reviews in Urology
    |September 21, 2006
    PubMed

    Insights

    Advanced renal cell carcinoma (RCC) treatment remains challenging. Current research in gene and immune therapy offers new hope for patients with metastatic RCC, focusing on genetic alterations and immune system components.

    Area of Science:

    • Oncology
    • Immunology
    • Genetics

    Background:

    • Advanced renal cell carcinoma (RCC) presents significant therapeutic challenges.
    • Understanding genetic alterations and immune dysregulation is crucial for effective RCC treatment.
    • Despite advances, curing advanced RCC remains elusive.

    Purpose of the Study:

    • To review the current role of immunotherapy and gene therapy in managing metastatic RCC.
    • To highlight the importance of genetic and immune-based strategies for advanced RCC.
    • To provide an overview of ongoing clinical trials in RCC gene and immune therapy.

    Main Methods:

    • Review of current literature on immunotherapy and gene therapy for metastatic RCC.
    • Analysis of the role of genetic alterations and immune dysregulations in RCC.
    • Compilation of information on active clinical trials in gene and immune therapy for RCC.

    Main Results:

    • Immunotherapy and gene therapy are emerging as promising strategies for advanced RCC.
    • Targeting specific genetic alterations and leveraging immune system components show potential.
    • Ongoing clinical trials are actively investigating these novel therapeutic approaches.

    Conclusions:

    • Future RCC therapy will likely integrate gene and immune-based approaches.
    • Investigative efforts in gene and immune therapy offer improved prospects for advanced RCC patients.
    • Continued research and clinical trials are essential for advancing RCC treatment outcomes.

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