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The aging bladder.

M B Siroky

    Reviews in Urology
    |September 21, 2006
    PubMed
    Summary
    This summary is machine-generated.

    Aging commonly causes lower urinary tract symptoms due to bladder dysfunction. This review examines the mechanisms behind age-related bladder changes and symptoms in older adults.

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    Area of Science:

    • Gerontology
    • Urology
    • Physiology

    Background:

    • Lower urinary tract symptoms (LUTS) are common in aging but underlying mechanisms are poorly understood.
    • Age-related changes include reduced bladder capacity, detrusor overactivity, and impaired urinary flow.
    • Differentiating aging-related symptoms from those of comorbid conditions is crucial.

    Purpose of the Study:

    • To review current data on the mechanisms of age-related bladder dysfunction.
    • To highlight the need for further investigation into these mechanisms.
    • To differentiate aging effects from other conditions causing LUTS.

    Main Methods:

    • Review of existing literature, including muscle bath studies of bladder tissue.
    • Analysis of in vivo studies using animal models of aging.

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  • Examination of clinical data from aging human populations.

    • Main Results:

    • Aging is associated with significant changes in bladder function and capacity.
    • Specific age-related alterations in contractility and urethral function are observed.
    • Clinical studies show increased postvoid residual volume and decreased flow rates with age.

    Conclusions:

    • Age-related bladder dysfunction is multifactorial, involving tissue and functional changes.
    • Further research is needed to fully elucidate these mechanisms.
    • Understanding these changes is key to managing LUTS in the elderly.