Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Radical Prostatectomy or Observation for Clinically Localized Prostate Cancer: Extended Follow-up of the Prostate Cancer Intervention Versus Observation Trial (PIVOT)" [Eur Urol 77 (2020) 713-24].

European urology·2021
Same author

The Clinical Cell-Cycle Risk (CCR) Score Is Associated With Metastasis After Radiation Therapy and Provides Guidance on When to Forgo Combined Androgen Deprivation Therapy With Dose-Escalated Radiation.

International journal of radiation oncology, biology, physics·2021
Same author

Personalizing Localized Prostate Cancer: Validation of a Combined Clinical Cell-cycle Risk (CCR) Score Threshold for Prognosticating Benefit From Multimodality Therapy.

Clinical genitourinary cancer·2021
Same author

Reply to Roderick C.N. van den Bergh, Massimo Valerio, Derya Tilki, and Giorgio Gandaglia's Letter to the Editor re: Timothy J. Wilt, Tien N. Vo, Lisa Langsetmo, et al. Radical Prostatectomy or Observation for Clinically Localized Prostate Cancer: Extended Follow-up of the Prostate Cancer Intervention Versus Observation Trial (PIVOT). Eur Urol. In press. http://dx.doi.org/10.1016/j.eururo.2020.02.009.

European urology·2020
Same author

Radical Prostatectomy or Observation for Clinically Localized Prostate Cancer: Extended Follow-up of the Prostate Cancer Intervention Versus Observation Trial (PIVOT).

European urology·2020
Same author

Extracapsular extension on MRI indicates a more aggressive cell cycle progression genotype of prostate cancer.

Abdominal radiology (New York)·2019

Related Experiment Video

Updated: Jul 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Prostatic intraepithelial neoplasia: an overview.

Michael K Brawer

    Reviews in Urology
    |September 21, 2006
    PubMed
    Summary

    Prostatic intraepithelial neoplasia (PIN) is a precursor to prostate cancer. Identifying high-grade PIN (HGPIN) indicates malignancy risk and may benefit from androgen deprivation therapy for chemoprevention.

    Area of Science:

    • Urology
    • Oncology
    • Pathology

    Background:

    • Prostatic intraepithelial neoplasia (PIN) is the primary precursor to prostatic carcinoma.
    • High-grade PIN (HGPIN) shares cytologic, molecular, and genetic markers with prostate cancer.
    • HGPIN incidence and severity increase with age and are highest in the prostate's peripheral zone.

    Purpose of the Study:

    • To review the established precursor role of PIN in prostatic carcinoma.
    • To highlight diagnostic features and patterns of HGPIN.
    • To discuss the clinical significance and potential chemopreventive strategies for HGPIN.

    Main Methods:

    • Review of established literature on prostatic intraepithelial neoplasia.
    • Analysis of cytologic features and patterns of HGPIN.

    More Related Videos

    Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
    08:38

    Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

    Published on: August 28, 2013

    Related Experiment Videos

    Last Updated: Jul 19, 2026

    A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
    07:25

    A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

    Published on: March 6, 2018

    Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
    08:38

    Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

    Published on: August 28, 2013

  • Evaluation of clinical significance and therapeutic interventions.

    • Main Results:

    • Prominent nucleoli in duct structures are key identifiers of PIN.
    • Four patterns of HGPIN (tufting, micropapillary, cribriform, flat) are described.
    • HGPIN identifies patients at risk for prostate cancer, with increased detection due to extended biopsy protocols.

    Conclusions:

    • HGPIN is a critical indicator of prostate cancer risk.
    • Androgen deprivation therapy may reduce PIN prevalence and serve as a chemopreventive measure.
    • Emerging research suggests selective estrogen receptor modulators might prevent HGPIN progression.