Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacologic treatment of erectile dysfunction.

William D Steers

    Reviews in Urology
    |September 21, 2006
    PubMed
    Summary

    Penile erection involves smooth muscle relaxation and blood flow changes, regulated by the central nervous system (CNS) and local stimuli. Medications targeting these mechanisms, like phosphodiesterase-5 inhibitors, effectively treat erectile dysfunction (ED).

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.

    International journal of impotence research·2018
    Same author

    A Review on Functional Electrical Stimulation of Bladder and Bowel in Spinal Cord Injury.

    Journal of long-term effects of medical implants·2018
    Same author

    Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway.

    Life sciences·2018
    Same author

    Establishing the subspecialty of female pelvic medicine and reconstructive surgery in the United States of America.

    Arab journal of urology·2015
    Same author

    Application of fibrin sealant at the urethrovesical anastomosis in robotic assisted radical prostatectomy: does it enable earlier Foley catheter and Jackson-Pratt drain removal?

    Journal of robotic surgery·2014
    Same author

    Falling short: causes and implications of drug shortages in the United States.

    The Journal of urology·2014

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Urology

    Background:

    • Penile erection is a complex physiological process involving smooth muscle relaxation, increased penile blood flow, and restricted venous outflow.
    • It is regulated by a spinal reflex influenced by central nervous system (CNS) stimuli (visual, imaginative, olfactory) and tactile penile stimuli.
    • The balance between contractile and relaxant factors in penile tissues governs erection rigidity.

    Purpose of the Study:

    • To elucidate the pharmacological mechanisms underlying penile erection.
    • To review how drugs affect the nerves and smooth muscle involved in erection.
    • To highlight the translation of pharmacological understanding into effective erectile dysfunction (ED) therapies.

    Main Methods:

    • Review of existing literature on the neuropharmacology of penile erection.
    • Analysis of drug effects on smooth muscle contractility and CNS regulation.
    • Examination of the efficacy of pharmacological agents in treating ED.

    Main Results:

    • Drugs can modulate penile erection by acting on regulating nerves or cavernous smooth muscle.
    • Agents that increase cytosolic calcium inhibit erection, while those lowering it promote smooth muscle relaxation and erection.
    • Phosphodiesterase type 5 inhibitors, alpha-adrenergic-receptor antagonists, and dopamine agonists are effective ED treatments targeting these pathways.

    Conclusions:

    • Understanding the pharmacology of penile erection is crucial for developing ED treatments.
    • Current therapies effectively leverage the physiological mechanisms of erection.
    • Advances in pharmacological research continue to improve ED management.

    Related Experiment Videos