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Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...

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Related Experiment Video

Updated: Jul 19, 2026

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

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Published on: November 30, 2016

Overlapping abdominal symptoms: why do GERD and IBS often coexist?

Nicholas J Talley1

  • 1Center for Enteric Neurosciences and Translational Epidemiological Research (C.E.N.T.E.R.), Mayo Clinic, Rochester, Minnesota 55905, USA.

Drugs of Today (Barcelona, Spain : 1998)
|September 21, 2006
PubMed
Summary

Gastroesophageal reflux disease (GERD), functional dyspepsia, and irritable bowel syndrome (IBS) frequently overlap, suggesting a shared underlying cause beyond mere prevalence. These conditions may indicate a common pathophysiological mechanism in some patients.

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Area of Science:

  • Gastroenterology and Internal Medicine

Background:

  • Gastroesophageal reflux disease (GERD), functional dyspepsia, and irritable bowel syndrome (IBS) are prevalent functional gastrointestinal disorders.
  • These conditions often coexist, prompting investigation into shared pathophysiological mechanisms.

Purpose of the Study:

  • To explore the potential common disease processes underlying the frequent coexistence of GERD, functional dyspepsia, and IBS.
  • To differentiate overlapping symptoms from high prevalence alone.

Main Methods:

  • Review of existing literature on the associations between GERD, functional dyspepsia, and IBS.
  • Analysis of reported pathophysiological links, including delayed gastric emptying and visceral hypersensitivity.

Main Results:

  • Coexistence of GERD, functional dyspepsia, and IBS suggests shared mechanisms.
  • Associations with asthma and bronchial hyperresponsiveness in IBS patients are noted.
  • Delayed gastric emptying and visceral hypersensitivity are observed in patients with overlapping IBS and dyspepsia.

Conclusions:

  • The overlap in GERD, functional dyspepsia, and IBS may stem from common pathophysiological processes in a subset of patients.
  • Attributing overlapping symptoms solely to high prevalence may overlook underlying shared disease mechanisms.