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Related Experiment Video

Updated: Jul 19, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

The complete remission concept.

Hubert Mönnikes¹

¹Division of Hepatology, Gastroenterology and Endocrinology, Charite - University Medical Center, Campus Virchow, Berlin, Germany.

Drugs of Today (Barcelona, Spain : 1998)

|September 21, 2006

Summary

A new method combines symptom assessment and endoscopic findings to redefine complete remission for gastroesophageal reflux disease (GERD). This approach accurately measures treatment effectiveness by evaluating both symptom relief and esophageal healing.

Area of Science:

Gastroenterology
Clinical Therapeutics
Patient-Reported Outcomes

Background:

Gastroesophageal reflux disease (GERD) diagnosis and treatment efficacy assessment are complicated by the dissociation between esophageal lesions and reported symptoms.
Traditional methods often fail to capture the full picture of GERD, leading to challenges in evaluating treatment outcomes.
A unified approach is needed to simultaneously assess symptom resolution and endoscopic healing.

Purpose of the Study:

To introduce a redefined concept of complete remission for GERD that integrates both symptom control and endoscopic healing.
To present the ReQuest(TM)/LA-classification as a novel tool for comprehensively assessing GERD treatment efficacy.
To enable more accurate clinical characterization and outcome measurement in GERD patients.

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Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

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Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

Main Methods:

Development of the Symptomatic Reflux Questionnaire (ReQuest(TM)), a validated scale measuring seven dimensions of GERD symptoms.
Adaptation of the Los Angeles classification for endoscopic assessment of esophageal lesions.
Combination of ReQuest(TM) with the adapted Los Angeles classification to create a unified assessment tool.

Main Results:

The ReQuest(TM) questionnaire effectively measures frequency and intensity across various GERD symptom dimensions.
The combined ReQuest(TM)/LA-classification links symptom assessment with objective endoscopic findings.
This integrated approach provides a single, global measure for evaluating treatment outcomes in GERD.

Conclusions:

The redefined concept of complete remission, incorporating both symptom and endoscopic parameters, offers a more accurate measure of GERD treatment success.
The ReQuest(TM)/LA-classification is a valuable tool for detailed clinical characterization and outcome assessment in GERD management.
This integrated approach facilitates a comprehensive understanding of treatment efficacy in GERD patients.