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Updated: Jul 19, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

MR in oncology drug development.

Susan M Galbraith¹

¹Clinical Discovery, Bristol-Myers Squibb, Princeton, NJ 08453-4000, USA. susan.galbraith@bms.com

NMR in Biomedicine

|September 21, 2006

Summary

Magnetic resonance (MR) imaging and spectroscopy aid drug development by studying tumor microvasculature and metabolism. Standardized methods and nomenclature are needed for comparing novel therapeutics and improving clinical trial design.

Area of Science:

Oncology
Medical Imaging
Pharmacology

Background:

Magnetic resonance (MR) techniques are crucial for preclinical and clinical drug development.
MR aids in studying tumor microvasculature and metabolism following anti-cancer agent treatment.

Purpose of the Study:

To review the application of MR in drug development, focusing on tumor microvasculature and metabolism.
To discuss the advantages and disadvantages of various MR techniques and analyze clinical trial data.

Main Methods:

Review of preclinical and clinical experimental data using MR techniques.
Analysis of contrast-enhanced and non-contrast-enhanced MR methods.
Examination of data from clinical trials employing MR for therapeutic assessment.

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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

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Published on: January 7, 2019

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Main Results:

Despite consensus documents, clinical trials often use non-standardized MR methods and nomenclature.
Inconsistent methodologies hinder the comparison of novel therapeutics and clinical trial results.
Lack of multicenter trial data on technique reproducibility is evident.

Conclusions:

Standardization of MR techniques and nomenclature is essential for effective drug development and clinical trial interpretation.
Further multicenter studies are needed to establish reproducibility and guide clinical trial design.
Consistent MR application will facilitate the evaluation of anti-vascular and anti-cancer agents.