Related Experiment Video

Updated: Jul 19, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

MR in oncology drug development

Susan M Galbraith1

  • 1Clinical Discovery, Bristol-Myers Squibb, Princeton, NJ 08453-4000, USA. susan.galbraith@bms.com

NMR in Biomedicine
|September 21, 2006
PubMed

Insights

Magnetic resonance (MR) imaging and spectroscopy aid drug development by studying tumor microvasculature and metabolism. Standardized methods and nomenclature are needed for comparing novel therapeutics and improving clinical trial design.

Area of Science:

  • Oncology
  • Medical Imaging
  • Pharmacology

Background:

  • Magnetic resonance (MR) techniques are crucial for preclinical and clinical drug development.
  • MR aids in studying tumor microvasculature and metabolism following anti-cancer agent treatment.

Purpose of the Study:

  • To review the application of MR in drug development, focusing on tumor microvasculature and metabolism.
  • To discuss the advantages and disadvantages of various MR techniques and analyze clinical trial data.

Main Methods:

  • Review of preclinical and clinical experimental data using MR techniques.
  • Analysis of contrast-enhanced and non-contrast-enhanced MR methods.
  • Examination of data from clinical trials employing MR for therapeutic assessment.

Main Results:

  • Despite consensus documents, clinical trials often use non-standardized MR methods and nomenclature.
  • Inconsistent methodologies hinder the comparison of novel therapeutics and clinical trial results.
  • Lack of multicenter trial data on technique reproducibility is evident.

Conclusions:

  • Standardization of MR techniques and nomenclature is essential for effective drug development and clinical trial interpretation.
  • Further multicenter studies are needed to establish reproducibility and guide clinical trial design.
  • Consistent MR application will facilitate the evaluation of anti-vascular and anti-cancer agents.

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...