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Updated: Jul 19, 2026
07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
[Complex regional pain syndrome type I induced by phenobarbital]
1Clinical Epilepsy Unit, Department of Neurosurgery, Yokohama City University Hospital, Yokohama, Japan.
No to Shinkei = Brain and Nerve
|September 22, 2006
Summary
Phenobarbital (PB) can induce Complex Regional Pain Syndrome type I (CRPS-I), characterized by severe pain and swelling. Early diagnosis and PB withdrawal are crucial for patient recovery and improved quality of life.
Area of Science:
- Neurology
- Pain Medicine
- Pharmacology
Context:
- Complex Regional Pain Syndrome type I (CRPS-I) is a debilitating condition often triggered by a noxious event.
- The association between phenobarbital (PB) and CRPS-I is increasingly recognized but not widely understood.
- This study investigates the incidence and characteristics of PB-induced CRPS-I.
Purpose:
- To assess the incidence, clinical features, diagnostic findings, and risk factors of CRPS-I in patients treated with phenobarbital (PB).
- To evaluate the effectiveness of PB withdrawal and other treatments for PB-induced CRPS-I.
Summary:
- Six out of 99 patients treated with PB developed CRPS-I, presenting with severe pain, allodynia, swelling, discoloration, and sweating.
- CRPS-I manifested bilaterally in some patients, with onset averaging 9.7 weeks after starting PB.
- Treatment involved PB reduction, with prednisone and/or Neurotropin, leading to symptom improvement, particularly pain and edema.
Impact:
- Highlights the importance of recognizing PB as a potential cause of CRPS-I.
- Emphasizes early diagnosis and prompt discontinuation of PB for effective management and improved patient outcomes.
- Suggests that age and PB dosage may be risk factors, warranting further investigation.
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