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Synthesis and characterization of water-soluble and photostable L-DOPA dendrimers
Shengzhuang Tang1, Lynda J Martinez, Ajit Sharma
1Department of Chemistry, Central Michigan University, Mt. Pleasant, Michigan 48859, USA.
Abstract:
A small drug molecule, L-DOPA, was converted into well-defined dendritic macromolecules. Their monodisperse nature was shown by NMR, MALDI-TOF-MS, and PAGE. A third-generation L-Dopa dendrimer contained 30 L-Dopa residues, which made up its core, branches, and periphery. Individual L-Dopa moieties in the dendrimer were connected to one another via hydrolyzable diester linkages. These Dopa dendrimers showed a 20-fold increase in aqueous solubility and enhanced photostability in solutions over L-Dopa under identical conditions.
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