Related Experiment Video
Updated: Jul 19, 2026

Quantitative 31P NMR Analysis of Lignins and Tannins
Published on: August 2, 2021
The 1H NMR method for the determination of the absolute configuration of 1,2,3-prim,sec,sec-triols
Enrique Lallana1, Félix Freire, José Manuel Seco
1Departamento de Química Organica and Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Abstract:
The absolute configuration of 1,2,3-prim,sec,sec-triols can be assigned by comparison of the 1H NMR spectra of the tris-(R)- and the tris-(S)-MPA ester derivatives. An experimental demonstration of this correlation with 24 triols of known absolute configuration and a protocol using two parameters-Deltadelta(RS)(H3) and the difference between Deltadelta RS (H2) and Deltadelta RS (H3) = absolute value (Delta(Deltadelta RS))-for its application to the determination of the absolute configuration of other triols are presented.
Related Concept Videos
¹H NMR: Complex Splitting
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied first.
2D NMR: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC)
¹H NMR of Conformationally Flexible Molecules: Temporal Resolution
¹H NMR of Conformationally Flexible Molecules: Variable-Temperature NMR
¹H NMR Signal Integration: Overview
NMR Spectroscopy of Benzene Derivatives

