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Related Experiment Videos

Primary hemostasis in hemodilution--2) Infusion solutions.

G Dietrich1, D Orth, W Haupt

  • 1Department of Transfusion Medicine and Coagulation Physiology, University Clinics, Marburg FRG.

Infusionstherapie (Basel, Switzerland)
|August 1, 1990
PubMed
Summary

Different infusion solutions impact bleeding times. Saline and albumin significantly prolong bleeding, while high molecular weight hydroxyethyl starch (HES) and dextran show minimal effects at lower volumes. Autologous plasma is the preferred substitute for hemodiluted patients.

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Area of Science:

  • Anesthesiology
  • Hematology
  • Surgical Innovation

Background:

  • Infusion solutions are critical for managing blood loss during surgery.
  • Preoperative hemodilution and intraoperative fluid replacement strategies are common.
  • The impact of various crystalloid and colloid solutions on hemostasis requires detailed investigation.

Purpose of the Study:

  • To evaluate the effect of common infusion solutions on primary hemostasis.
  • To compare the hemostatic impact of saline, albumin, dextran, gelatin, and hydroxyethyl starch (HES).
  • To determine the optimal fluid substitute for hemodiluted patients.

Main Methods:

  • In-vitro bleeding test (IVBT) utilized to assess primary hemostasis.
  • Blood samples were artificially diluted to varying hematocrit levels with constant platelet concentration.

Related Experiment Videos

  • The influence of saline 0.9%, albumin 5%, dextran 6%, gelatin 3.5%, and HES (40,000 and 450,000 MW) was analyzed.

    • Main Results:

    • All tested infusion solutions increased bleeding times proportionally to the volume administered.
    • Saline and albumin demonstrated the most significant prolongation of bleeding times.
    • High molecular weight HES and dextran exhibited minimal impairment on hemostasis when volumes were below 20% of blood volume.

    Conclusions:

    • The choice of infusion solution significantly affects primary hemostasis.
    • Saline and albumin solutions pose a higher risk of impaired hemostasis compared to HES and dextran.
    • Autologous plasma is recommended as the superior substitute for hemodilution exceeding 20% of blood volume.