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Intraendothelial tubular aggregates in experimental wounds
The British Journal of Dermatology
|August 1, 1975
Summary
Tubular aggregates in blood vessels were observed in healing wounds of patients on corticosteroids and healthy individuals. These structures, previously linked to autoimmune diseases, likely originate from regenerating endothelium, not viruses.
Area of Science:
- Dermatology
- Pathology
- Cell Biology
Background:
- Intraendothelial tubular aggregates have been observed in various connective tissue and autoimmune diseases.
- Their origin and significance, particularly in wound healing, remain unclear.
- Previous hypotheses suggested a viral etiology for these structures.
Purpose of the Study:
- To investigate the presence and nature of intraendothelial tubular aggregates in healing wounds.
- To determine the potential association of these aggregates with systemic corticosteroid use.
- To explore the morphogenesis and significance of tubular aggregates in regenerating endothelium.
Main Methods:
- Light microscopy examination of dermal blood vessels in superficial wound biopsies.
- Comparison of findings in patients receiving systemic corticosteroids and healthy controls.
- Histopathological analysis of normal and wounded skin samples.
Main Results:
- Tubular aggregates were identified in small dermal blood vessels of healing wounds in both corticosteroid-treated patients and healthy subjects.
- These inclusions were absent in normal, unwounded skin from both groups.
- The structures were not found to be of viral origin.
Conclusions:
- The findings suggest that intraendothelial tubular aggregates in healing wounds are likely a product of regenerating endothelium.
- The presence of these aggregates is not exclusive to autoimmune diseases and can occur during normal wound healing.
- The study does not support a viral etiology for these endothelial structures.