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Vascular endothelial growth factor and children featuring nasal polyps
Ko-Hsin Hu1, Fei-Peng Lee, Ya-Jian Cheng
1Department of Otorhinolaryngology--Head and Neck Surgery, Taoyuan General Hospital, Department of Health, Taoyuan, Taiwan.
International Journal of Pediatric Otorhinolaryngology
|September 22, 2006
Summary
Vascular endothelial growth factor (VEGF) expression and blood vessel density are significantly higher in pediatric nasal polyps. These factors correlate with polyp size, indicating VEGF
Area of Science:
- Otolaryngology
- Pathology
- Molecular Biology
Background:
- Chronic rhinosinusitis (CRS) in children can lead to nasal polyps.
- The role of vascular endothelial growth factor (VEGF) in pediatric nasal polyp development is not fully understood.
Purpose of the Study:
- To investigate VEGF expression in pediatric nasal polyps.
- To determine the correlation between VEGF expression, blood vessel density, and nasal polyp size.
Main Methods:
- Sixty children with CRS were studied; 30 had nasal polyps.
- Biopsy specimens from polyps and ethmoid sinuses were analyzed using immunohistochemistry for VEGF and endothelial cell markers.
- VEGF levels and blood vessel density were quantified under light microscopy.
Main Results:
- VEGF-expressing cells and blood vessel density were significantly higher in nasal polyps compared to control sinus mucosa (P<0.01).
- VEGF expression was primarily located in vascular endothelium and mast cells within polyps.
- Both VEGF levels and blood vessel density positively correlated with nasal polyp size (P<0.05).
Conclusions:
- Elevated VEGF expression and increased blood vessel density are characteristic of pediatric nasal polyps.
- VEGF plays a role in the pathogenesis of nasal polyps in children with CRS.
- These findings suggest VEGF as a potential therapeutic target.
