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Updated: Jul 19, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
Published on: September 21, 2011
Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists
Steven J Richards1, Thomas W von Geldern, Peer Jacobson
1Metabolic Disease Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. steven.richards@abbott.com <steven.richards@abbott.com>
Abstract:
A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy.
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