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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Related Experiment Video

Updated: Jul 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Immunological basis of systemic sclerosis.

J-P Zuber1, F Spertini

  • 1Division of Immunology and Allergy, CHUV, BH 18/707, 1011 Lausanne, Switzerland. jean-philippe.zuber@chuv.ch

Rheumatology (Oxford, England)
|September 22, 2006
PubMed
Summary

Systemic sclerosis involves immune system activation, leading to fibrosis and vascular issues. Understanding these immunological processes is key to developing new treatments for this complex disease.

Area of Science:

  • Immunology
  • Rheumatology
  • Pathophysiology

Background:

  • Systemic sclerosis (SSc) is a fibrotic disease with unknown causes.
  • It features immune system abnormalities and microvasculature changes.
  • Current understanding suggests immune activation drives SSc's vascular and fibrotic pathology.

Purpose of the Study:

  • To discuss the immunological aspects of Systemic Sclerosis.
  • To explore the altered immunological processes in SSc patients.
  • To provide insights into the complex pathogenesis of SSc.

Main Methods:

  • Review of recent studies on SSc pathogenesis.
  • Analysis of immunological abnormalities in SSc.
  • Discussion of T-cell and B-cell roles in SSc.

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

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Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Main Results:

  • Activated T-cells infiltrate skin lesions and produce IL-4, a profibrotic cytokine.
  • T-cells are essential for autoantibody production in SSc.
  • B-cells, potentially via CD19, may contribute to fibrosis development.

Conclusions:

  • The immune system's activation is a critical factor in SSc.
  • Understanding immunological alterations is vital for SSc research.
  • Further investigation into immune mechanisms may reveal therapeutic targets.