Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thalamic projections to sensorimotor cortex in the newborn macaque.

C Darian-Smith1, I Darian-Smith, S S Cheema

  • 1Department of Anatomy, University of Melbourne, Parkville, Victoria, Australia.

The Journal of Comparative Neurology
|September 1, 1990
PubMed
Summary

Thalamocortical projections to the macaque sensorimotor cortex are established early. Newborn macaques show distinct projection patterns, including pulvinar projections, that mature by adulthood.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis).

Journal of medical primatology·2023
Same author

Photon spectra in NPL standard monoenergetic neutron fields.

Radiation protection dosimetry·2023
Same author

Incomplete Freund's adjuvant enhances locomotor performance following spinal cord injury.

European journal of neurology·2005
Same author

Induction of endogenous neural precursors in mouse models of spinal cord injury and disease.

European journal of neurology·2005
Same author

Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS.

European journal of neurology·2005
Same author

IgA-dominant glomerulonephritis associated with hepatitis A.

Clinical nephrology·2004

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Primate Neuroanatomy

Background:

  • Thalamocortical projections are crucial for sensorimotor function.
  • Understanding the developmental trajectory of these projections is key to comprehending brain maturation.

Purpose of the Study:

  • To map thalamocortical projections in newborn macaques.
  • To compare early projection patterns with those in mature animals.
  • To investigate the developmental changes in thalamocortical organization.

Main Methods:

  • Utilized retrograde fluorescent dyes to label thalamocortical neurons in newborn and mature macaques.
  • Employed double-labeling techniques to identify neurons with overlapping projections.
  • Compared projection patterns across different developmental stages.

Related Experiment Videos

Main Results:

  • Thalamocortical projections to the sensorimotor cortex are fully established by embryonic days 146-150.
  • Newborn macaques exhibit significant overlap in thalamocortical neuron projections.
  • Extensive projections from the anterior pulvinar nucleus to motor areas were observed in newborns, diminishing by adulthood.

Conclusions:

  • Thalamocortical pathways to the macaque sensorimotor cortex are largely formed prenatally.
  • Development involves refinement of projection patterns, including the reduction of pulvinar inputs.
  • Epigenetic factors may influence these postnatal developmental events.