Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathway mapping tools for analysis of high content data.

Sean Ekins1, Yuri Nikolsky, Andrej Bugrim

  • 1GeneGo, Jerkintown, PA, USA.

Methods in Molecular Biology (Clifton, N.J.)
|September 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy, Structure-Activity Relationship, and Mode of Action Studies of a New Generation of Acridine/Acridone-Based Antimalarials.

ACS infectious diseases·2026
Same author

MegaTrans-machine learning models for drug transporters corresponding to the FDA guidance.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Repurposing Clinical Candidates for Nipah and Hendra Viruses.

ACS infectious diseases·2026
Same author

Enhanced Antiviral Activity of Novel Umifenovir Derivatives against SARS-CoV-2: Insights from an International Collaborative Study.

ACS omega·2026
Same author

Palmitoyl-protein thioesterase-1 in health and disease.

Trends in pharmacological sciences·2026
Same author

Enzyme replacement therapy for CLN1 batten disease that crosses the blood-brain-barrier.

Molecular genetics and metabolism·2026

This review explores systems biology approaches, integrating diverse data like genomics and proteomics. It highlights pathway databases and network tools, including GeneGo

Area of Science:

  • Computational biology
  • Systems biology
  • Bioinformatics

Background:

  • Human biology's complexity necessitates computational approaches for data integration.
  • Systems biology analyzes metabolic and signaling pathways using multi-omics data (genomics, proteomics, metabolomics).
  • High-content screening assays also contribute to systems biology knowledge.

Purpose of the Study:

  • To review pathway databases and biological network tools for systems biology.
  • To describe integrated data-mining tools for biological network construction.
  • To focus on GeneGo's MetaCore and MetaDrug platforms.

Main Methods:

  • Literature review of pathway databases and network analysis tools.
  • Description of computational approaches for integrating multi-omics data.

Related Experiment Videos

  • Detailed explanation of GeneGo's MetaCore and MetaDrug for biological network analysis.

    • Main Results:

    • Summary of available pathway databases and biological network tools.
    • Discussion of the applicability of these tools to genomics, proteomics, metabolomics, and high-content screening data.
    • Detailed overview of MetaCore and MetaDrug for integrated data mining and network building.

    Conclusions:

    • Systems biology requires integrated computational approaches for analyzing complex biological data.
    • Pathway databases and network tools are essential for understanding biological systems.
    • GeneGo's MetaCore and MetaDrug offer powerful solutions for building biological networks from diverse datasets.