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Updated: Jul 19, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Factor V inhibitor: case report
Barbara Leus1, Katrien Devreese, Jan van den Bossche
1Clinical Laboratory, General Hospital Middelheim, Antwerp, Belgium. barbaraleus@hotmail.com
Acquired inhibitors to coagulation factors are rare, certainly those directed against factor V. A total of around 150 cases have so far been reported, of which the greater part was due to bovine thrombin exposure. We report the case of a patient who developed a factor V inhibitor during a postoperative period. This report describes possible aetiologies, varying clinical conditions and treatment possibilities as described in the literature. Furthermore, this case report is an example of the often unpredictable disease progression in a patient with existence of a factor V inhibitor.
Acquired inhibitors to coagulation factors are rare, certainly those directed against factor V. A total of around 150 cases have so far been reported, of which the greater part was due to bovine thrombin exposure. We report the case of a patient who developed a factor V inhibitor during a postoperative period. This report describes possible aetiologies, varying clinical conditions and treatment possibilities as described in the literature. Furthermore, this case report is an example of the often unpredictable disease progression in a patient with existence of a factor V inhibitor.
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