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Updated: Jul 19, 2026

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper

Cultivating Ex Vivo Patient-Derived Glioma Organoids Using a Tissue Chopper

Published on: January 19, 2024

Glioma in the elderly.

Florence Laigle-Donadey¹, Jean-Yves Delattre

¹Service de Neurologie Mazarin, Hôpital de la Pitié-Salpêtrière - Assistance Publique-Hôpitaux de Paris, Paris, France. florence.laigle-donadey@psl.ap-hop-paris.fr

Current Opinion in Oncology

|September 22, 2006

Summary

Management of gliomas in elderly patients is evolving. Recent studies show older adults with malignant gliomas can benefit from radiotherapy, surgery, or chemotherapy, challenging previous approaches.

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Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases

Published on: June 28, 2019

Area of Science:

Neuro-oncology
Geriatric Medicine
Clinical Oncology

Background:

The incidence of gliomas is rising in the elderly population.
Increasing age is a significant negative prognostic factor for glioma patients.
Optimal management strategies for elderly glioma patients are often unsettled due to exclusion from clinical trials.

Purpose of the Study:

To update available data on the management of gliomas in the elderly.
To review current evidence regarding treatment efficacy in older glioma patients.
To discuss factors influencing treatment decisions for elderly individuals with gliomas.

Main Methods:

Review of prospective randomized studies.
Analysis of recent clinical trial data.
Synthesis of evidence on surgical, radiotherapeutic, and chemotherapeutic interventions.

Main Results:

Prospective randomized studies confirm the benefit of radiotherapy in older patients with malignant gliomas.
An accelerated course of irradiation is validated as effective in this population.
Evidence suggests older patients (70-80 years) may benefit from surgery, radiotherapy, or chemotherapy.

Conclusions:

The management approach for elderly glioma patients is shifting from nihilistic to active strategies.
Performance status, quality of life, and comorbidities are crucial considerations for treatment.
Future research should focus on designing specific treatment schedules tailored for the elderly glioma population.