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Updated: Jul 19, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
Published on: July 3, 2013
[Is there a role for calcium antagonists when beta-adrenergic blockade therapy is contraindicated in post-myocardial
Pierre-Vladimir Ennezat1, Jean-Luc Auffray, Julie Darchis
1Hôpital cardiologique, Lille, France. pv-ennezat@chru-lille.fr
Abstract:
The purpose of this paper is to examine the eventual benefits of treatment with calcium channel blockers in post-myocardial infarction, through an overview of main placebo-controlled trials that have been conducted to test this therapeutic in acute coronary syndromes. It appears obvious that the vast majority of these trials was conducted in the pre-reperfusion era and failed to demonstrate a reduction in mortality. To conclude, the superiority of a therapy with calcium antagonists over a placebo in the management of post-myocardial infarction remains unknown. In contrast, adverse effects associated with the prescription of calcium antagonists are well known.
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