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Updated: Jul 19, 2026
08:54
Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
[Paediatric specificity of antifungals use]
Marie-Dominique Tabone1, Nathalie Le Guyader, Guy Leverger
1Service d'Hémato-Oncologie Pédiatrique, Hôpital Trousseau, Paris, France. marie-dominique.tabone@trs.aphp.fr
Therapie
|September 23, 2006
Summary
Optimizing antifungal use in children requires considering their unique mycoses epidemiology and pharmacokinetics. Limited data and rare approvals necessitate careful strategy development for pediatric antifungal treatment.
Area of Science:
- Pediatric Pharmacology
- Mycology
- Infectious Diseases
Context:
- Antifungal drug use in children presents unique challenges due to varying pharmacokinetics and limited approved agents.
- Epidemiology of fungal infections (mycoses) in pediatric populations differs from adults, impacting treatment specificity.
- Adverse event profiles and drug interactions in children require careful consideration.
Purpose:
- To highlight the specific considerations for antifungal use in pediatric patients.
- To underscore the scarcity of pharmacokinetic data and approved antifungal agents for children.
- To emphasize the need for tailored treatment strategies based on individual pediatric cases.
Summary:
- Antifungal efficacy in children is influenced by local mycoses epidemiology and age-dependent pharmacokinetics.
- Limited pharmacokinetic data and a scarcity of approved antifungal medications in France complicate pediatric treatment.
- Differences in adverse event frequency and potential drug interactions necessitate cautious prescribing in children.
Impact:
- Informing the development of evidence-based guidelines for pediatric antifungal therapy.
- Guiding clinicians in selecting appropriate antifungal agents and dosages for children.
- Promoting safer and more effective management of fungal infections in pediatric populations.
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