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Updated: Jul 19, 2026

Developing a Clinically Relevant Hemorrhagic Shock Model in Rats
Published on: March 22, 2024
[Mathematical modeling of cardiovascular system in patients with hemorrhage and hypothermia]
Abstract:
Mathematical modeling is the most expedient method for studying the response of human cardiovascular system to a combined effect of several external factors, in particular, hemorrhage and hypothermia. A complex mathematical model integrating models of the functional systems of human body and the physiological effects of disturbing factors can be used to study the combined effect of external factors. It allows the response of human body to various combinations of external effects of different intensities to be assessed with high accuracy. In addition, the model makes it possible to prognosticate the dynamics of changes in the cardiovascular system parameters from their initial variation. This facilitates prediction of the development of patient's state.
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