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Related Concept Videos

Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Vaccinations01:51

Vaccinations

Overview
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

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Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Persistence of vaccine-derived poliovirus following a mass vaccination campaign in Cuba: implications for stopping polio vaccination after global eradication.

International journal of epidemiology·2001
Same author

[Poliomyelitis outbreak caused by vaccine-derived virus in Haiti and the Dominican Republic].

Revista panamericana de salud publica = Pan American journal of public health·2001
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Strategies to eradicate rubella in the English-speaking Caribbean.

American journal of public health·2000
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Review of regional measles surveillance data in the Americas, 1996-99.

Lancet (London, England)·2000
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State of immunization in the Americas.

Infectious disease clinics of North America·2000
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[Endeavors to eradicate measles in the Americas].

Revista espanola de salud publica·2000

Related Experiment Video

Updated: Jul 19, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Is global measles eradication feasible?

C A de Quadros1

  • 1Sabin Vaccine Institute and Pan American Health Organization, Washington, DC, USA. ciro.dequadros@sabin.org

Current Topics in Microbiology and Immunology
|September 23, 2006
PubMed
Summary

Measles vaccination has dramatically reduced disease incidence. Global measles eradication is feasible, preventing hundreds of thousands of child deaths annually and costly epidemics.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Vaccinology

Background:

  • Measles is a highly contagious disease, historically infecting nearly all children.
  • Despite widespread vaccination programs since the 1980s, 800,000 deaths annually, primarily in Africa, highlight the need for eradication.
  • Child survival rates can be significantly improved by eliminating measles.

Purpose of the Study:

  • To assess the feasibility and impact of measles eradication.
  • To review progress towards measles elimination in the Americas.

Main Methods:

  • Analysis of global vaccination program data.
  • Review of measles transmission interruption in the Americas since 1994.
  • Case study of Venezuela's last indigenous measles case in 2002.

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Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

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Last Updated: Jul 19, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology
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Whole Genome Sequencing for Rapid Characterization of Rabies Virus Using Nanopore Technology

Published on: August 18, 2023

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

Main Results:

  • Measles is no longer endemic in the Americas, with transmission interrupted in most countries.
  • Three years have passed since the last indigenous measles case in Venezuela (September 2002).
  • Sustained interruption of measles transmission is achievable.

Conclusions:

  • Global measles eradication is feasible with appropriate strategies.
  • Eradication is a worthwhile investment to prevent child mortality and costly epidemics.
  • A measles-free world is an attainable goal.