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Antidepressant principles of the roots of Polygala tenuifolia
Mo-Chi Cheng1, Chia-Ying Li, Han-Chieh Ko
1Medical and Pharmaceutical Industry Technology and Development Center, Taipei County, Taiwan, Republic of China.
Abstract:
[(125)I]RTI-55-membrane binding assay-guided fractionation and separation of a water-soluble extract of the roots of Polygala tenuifolia gave five new oligosaccharide derivatives, polygalatenosides A-E (1-5). The structures of these new oligosaccharides were established on the basis of spectroscopic evidence. Polygalatenosides A and B (1 and 2) showed significant inhibitory activity, with IC(50) values of 30.0 and 6.04 microM, respectively, in this membrane binding assay and acted as norepinephrine reuptake inhibitors through blocking norepinephrine transport.
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