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Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale
Published on: August 16, 2018
Tirucallane, apotirucallane, and octanorapotirucallane triterpenes of Simarouba amara
Sumieya N J Grosvenor1, Keisha Mascoll, Stewart McLean
1Laboratory of Bioorganic Chemistry, Department of Biological & Chemical Sciences, The University of the West Indies, Cave Hill Campus, Bridgetown, P.O. Box 64, Barbados, BB11000.
Abstract:
A chemical investigation of the bark of Simarouba amara, collected in Barbados, resulted in the isolation of six new triterpenes (3-8), in addition to two known compounds, 3-oxatirucalla-7, 24-dien-23-ol (1) and niloticin (2). Compound 3 is a tirucallane triterpene, while compounds 4-7 are apotirucallane derivatives containing an epsilon-lactone in ring A. Compounds 6 and 7 were obtained as a mixture that could not be separated, while compound 8 is an octanorapotirucallane derivative that lacks the C(8) side chain. The structures of all compounds were determined by interpretation of physical data.
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