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Updated: Jul 19, 2026

Utilizing Thermal Shift Assay to Probe Substrate Binding to Selenoprotein O
Published on: August 9, 2024
Selenoproteins and their impact on human health through diverse physiological pathways
Behzad Moghadaszadeh1, Alan H Beggs
1Children's Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Abstract:
In the last few decades, the importance of selenium in human health has been the subject of numerous studies. It is believed that the physiological effects of selenium occur mainly through the function of selenoproteins, which incorporate selenium in the form of one or more selenocysteine residues. Recent advances in understanding the complex regulation of selenoprotein synthesis and functional characterization of several members of the selenoprotein family have contributed to an improved comprehension of the role(s) of selenium in human health and the great diversity of physiological pathways influenced by this trace element.
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