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Updated: Jul 19, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
Published on: October 3, 2012
Parkinson's disease and genetics
Jacobo Lester1, Enrique Otero-Siliceo
1Hospital de Clínicas José de San Martín, Huixquilucan, Estado de México, Mexico. jacobolester@hotmail.com
Background:
Idiopathic Parkinson disease (IPD) is a condition of unknown cause. Several factors are believed to contribute to its onset, and many studies have been conducted in search of the possible etiology of Parkinson disease.
Review Summary:
Genetic factors have become relevant when trying to explain the onset of Parkinson disease. The studies are divided into 2 categories: epidemiological and studies that analyze twins from families with members suffering from Parkinson disease, thus looking for the responsible genetic mutations. In this article we address this controversial topic, reviewing some of the most significant studies trying to provide evidence which relates genetics to Parkinson disease.
Conclusion:
We present current epidemiological studies and the most important genetic factors related to Parkinson disease, including the latest information currently available on each issue.
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