Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Prevention

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Mutations

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...

Mutations

Mutations

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Multiple Treatment Comparison of Eleven Disease-Modifying Drugs Used for Multiple Sclerosis.

Journal of clinical medicine research·2018

Same author

Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women' Lifestyle and Health Study.

BMC cancer·2015

Same author

Vitamin D intake, month the mammogram was taken and mammographic density in Norwegian women aged 50-69.

PloS one·2015

Same author

HPV catch-up vaccination of young women: a systematic review and meta-analysis.

BMC public health·2014

Same author

Breast cancer susceptibility variants and mammographic density phenotypes in norwegian postmenopausal women.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2014

Same author

Host characteristics, sun exposure, indoor tanning and risk of squamous cell carcinoma of the skin.

International journal of cancer·2014

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Generation and Genetic Manipulation of Human Cervical Organoids

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

Heritable and environmental components in cervical tumors.

Elisabeth Couto¹, Kari Hemminki

¹Department of Biosciences and Nutrition at Novum, Karolinska Institute, Huddinge, Sweden.

International Journal of Cancer

|September 23, 2006

Summary

Women with a family history of cervical cancer face a significantly higher risk. This suggests a strong genetic component, alongside environmental factors, contributing to familial cervical tumors.

More Related Videos

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

Related Experiment Videos

Last Updated: Jul 19, 2026

Generation and Genetic Manipulation of Human Cervical Organoids

Generation and Genetic Manipulation of Human Cervical Organoids

Published on: March 10, 2026

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

Area of Science:

Oncology
Genetics
Epidemiology

Background:

Cervical cancer exhibits familial aggregation, suggesting a potential genetic or shared environmental influence.
Understanding familial risk is crucial for identifying individuals susceptible to cervical tumors.

Purpose of the Study:

To quantify the familial risk associated with cervical cancer.
To investigate the heritable and environmental components contributing to familial cervical tumors.

Main Methods:

A case-control study involving 18,199 women with cervical cancer and 72,796 controls.
Analysis of risk based on the presence of cervical tumors in first-degree (mother, sister) and second-degree (grandmother, aunt) relatives.

Main Results:

Women with a mother or sister diagnosed with cervical cancer had a significantly higher risk (OR = 1.79).
Risk was also elevated with affected grandmothers or aunts (OR = 1.28), with no difference based on the maternal or paternal side.
A model estimated a heritable component of 71% and an environmental component of 29% for familial cervical tumors.

Conclusions:

Familial risk for cervical tumors is substantial, particularly with first-degree relatives.
Cervical cancer development likely involves complex multifactorial mechanisms, including both genetic predisposition and environmental exposures.
These findings underscore the importance of considering family history in cervical cancer risk assessment.