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Updated: Jul 19, 2026

MRM Microcoil Performance Calibration and Usage Demonstrated on Medicago truncatula Roots at 22 T
Published on: January 16, 2021
Extending the scope of NMR spectroscopy with microcoil probes
Frank C Schroeder1, Matthew Gronquist
1Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA. frank_schroeder@hms.harvard.edu
Abstract:
Capillary NMR (CapNMR) spectroscopy has emerged as a major breakthrough for increasing the mass-sensitivity of NMR spectroscopic analysis and enabling the combination of NMR spectroscopy with other analytical techniques. Not only is the acquisition of high-sensitivity spectra getting easier but the quality of CapNMR spectra obtained in many small-molecule applications exceeds what can be accomplished with conventional designs. This Minireview discusses current CapNMR technology and its applications for the characterization of mass-limited, small-molecule and protein samples, the rapid screening of small-molecule or protein libraries, as well as hyphenated techniques that combine CapNMR with other analytical methods.
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