Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperdynamic therapy for cerebral vasospasm.

H Hadeishi1, M Mizuno, A Suzuki

  • 1Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita.

Neurologia Medico-Chirurgica
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of nucleotide sequences that interact with a nuclear protein fraction in rRNA gene of Vicia faba.

Plant molecular biology·1992
Same author

[Surgical treatment of infected left atrial myxoma--a case report].

[Zasshi] [Journal]. Nihon Kyobu Geka Gakkai·1992
Same author

Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive lung disease.

Thorax·1992
Same author

cDNA cloning and sequence determination of the pheromone biosynthesis activating neuropeptide of the silkworm, Bombyx mori.

Biochemical and biophysical research communications·1992
Same author

A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos.

FEBS letters·1992
Same author

Mechanism of the reflex inhibition of micturition contractions of the urinary bladder elicited by acupuncture-like stimulation in anesthetized rats.

Neuroscience research·1992
Same journal

Long-term Outcomes of Hypo- and Conventional Fractionated Stereotactic Radiotherapy for Non-vestibular Schwannomas: A Retrospective Cohort Study from Ramathibodi Hospital.

Neurologia medico-chirurgica·2026
Same journal

A Coronal Hydrocephalic Index (Eo Index) for Predicting Shunt Responsiveness in Idiopathic Normal Pressure Hydrocephalus.

Neurologia medico-chirurgica·2026
Same journal

Safety and Effectiveness of Embolization via the Ophthalmic Artery with N-butyl Cyanoacrylate for Anterior Skull Base Meningiomas.

Neurologia medico-chirurgica·2026
Same journal

Electroencephalogram-based Objective Assessment of Surgical Expertise during Microvascular Anastomosis Training.

Neurologia medico-chirurgica·2026
Same journal

Time-to-maximum Analysis Using Rapid Processing of Perfusion and Diffusion Software for Assessment of the Risk of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.

Neurologia medico-chirurgica·2026
Same journal

Incidence and Outcomes of Flow Diverter Braid Deformation following Treatment with Non-DFT Wire Devices.

Neurologia medico-chirurgica·2026
See all related articles

Hyperdynamic therapy with dobutamine (DOB) effectively reversed neurological deficits in subarachnoid hemorrhage (SAH) patients with cerebral vasospasm. This treatment improved cerebral blood flow (CBF) without increasing blood pressure.

Area of Science:

  • Neurology
  • Neurosurgery
  • Critical Care Medicine

Background:

  • Cerebral vasospasm is a common complication after subarachnoid hemorrhage (SAH), leading to delayed neurological deficits.
  • Hyperdynamic therapy is a strategy to improve cerebral blood flow (CBF) in these patients.
  • The role of dobutamine (DOB) in managing SAH-induced vasospasm under controlled blood pressure (BP) and blood volume requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of hyperdynamic therapy using dobutamine (DOB) in patients with cerebral vasospasm following subarachnoid hemorrhage (SAH).
  • To assess the impact of DOB on cerebral blood flow (CBF) and neurological outcomes.
  • To determine the safety profile of this therapeutic approach in the postoperative setting.

Main Methods:

Related Experiment Videos

  • Forty-four patients undergoing aneurysm surgery for acute SAH received hydroxyethyl starch to prevent dehydration.
  • Twenty-four patients with prominent SAH on CT scans received dobutamine (DOB) to prevent cerebral ischemia.
  • Cerebral blood flow (CBF) was measured using the 133Xe intravenous injection method; cardiovascular function was monitored with Swan-Ganz catheters in a subset of patients.

    • Main Results:

    • Twelve of 44 patients (27%) developed delayed neurological deficits due to cerebral vasospasm.
    • Dobutamine (DOB) administration (8-25 µg/kg/min) reversed these neurological deficits.
    • In patients receiving DOB, CBF increased by up to 20% without significant changes in BP, and no cases of pulmonary edema or heart failure were observed.

    Conclusions:

    • Hyperdynamic therapy with dobutamine (DOB) is effective in reversing neurological deficits associated with cerebral vasospasm after SAH.
    • DOB improves CBF in SAH patients while maintaining normal blood pressure and blood volume, with a favorable safety profile.
    • This therapeutic strategy can prevent ischemic lesions and improve patient outcomes following subarachnoid hemorrhage.