Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory neurogenesis: genetic or environmental controls?

A I Farbman1

  • 1Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208.

Trends in Neurosciences
|September 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuronal cell death and population dynamics in the developing rat geniculate ganglion.

Neuroscience·2005
Same author

Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa.

The Journal of comparative neurology·2001
Same author

Post-traumatic olfactory dysfunction.

The Laryngoscope·2000
Same author

TGF-alpha and olfactory marker protein enhance mitosis in rat olfactory epithelium in vivo.

Neuroreport·2000
Same author

Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32).

Experimental neurology·2000
Same author

Comparison of neurotrophin and repellent sensitivities of early embryonic geniculate and trigeminal axons.

The Journal of comparative neurology·2000

Vertebrate olfactory neurons continuously regenerate throughout life. Their lifespan and maturity are regulated, with mature neurons retaining juvenile characteristics due to likely genetic controls.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Vertebrate olfactory neurons exhibit continuous neurogenesis, a unique characteristic among neurons.
  • This ongoing replacement suggests a dynamic system with regulated neuron lifespan and maturity.
  • Mature olfactory neurons display persistent juvenile features, hinting at underlying genetic regulation.

Purpose of the Study:

  • To explore the continuous replacement of vertebrate olfactory neurons.
  • To understand the regulatory mechanisms governing olfactory neuron lifespan and maturity.
  • To investigate the genetic basis for the retention of juvenile characteristics in mature olfactory neurons.

Main Methods:

  • Analysis of neurogenesis rates in vertebrate olfactory systems.

Related Experiment Videos

  • Experimental manipulation to alter sensory neuron lifespan.
  • Comparative studies of mature olfactory neurons versus other neuronal types.

    • Main Results:

    • Olfactory neuron neurogenesis is a lifelong process in vertebrates.
    • The lifespan and developmental timing of olfactory neurons can be modulated.
    • Mature olfactory neurons maintain characteristics typically seen in immature cells.

    Conclusions:

    • The continuous regeneration of olfactory neurons is a key feature of the vertebrate sensory system.
    • Genetic factors likely play a crucial role in maintaining the immature state of mature olfactory neurons.
    • Further research into these genetic controls could reveal novel insights into neuronal development and aging.