Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hyperosmolar volume replacement in heart surgery].

J Boldt1, B Zickmann, A Thiel

  • 1Abteilung Anaesthesiologie und Operative Intensivmedizin, Justus-Liebig-Universität Giessen.

Der Anaesthesist
|August 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Upper Limit on the Photoproduction Cross Section of the Spin-Exotic π_{1}(1600).

Physical review letters·2025
Same author

Search for Rare Decays of D_{s}^{+} to Final States π^{+}e^{+}e^{-}, ρ^{+}e^{+}e^{-}, π^{+}π^{0}e^{+}e^{-}, K^{+}π^{0}e^{+}e^{-}, and K_{S}^{0}π^{+}e^{+}e^{-}.

Physical review letters·2024
Same author

Strong and Weak CP Tests in Sequential Decays of Polarized Σ^{0} Hyperons.

Physical review letters·2024
Same author

High-Statistics Measurement of Collins and Sivers Asymmetries for Transversely Polarized Deuterons.

Physical review letters·2024
Same author

Precise Measurement of Born Cross Sections for e^{+}e^{-}→DD[over ¯] at sqrt[s]=3.80-4.95  GeV.

Physical review letters·2024
Same author

Final COMPASS Results on the Transverse-Spin-Dependent Azimuthal Asymmetries in the Pion-Induced Drell-Yan Process.

Physical review letters·2024
Same journal

[Promoting young academics in anesthesiology: factors for an attractive internship].

Der Anaesthesist·2022
Same journal

[Respiratory support in COVID-19: all in due time!]

Der Anaesthesist·2022
Same journal

[Noninvasive respiratory support and invasive ventilation in COVID‑19 : Where do we stand today?]

Der Anaesthesist·2022
Same journal

[Management of acutely decompensated liver cirrhosis in emergency and critical care medicine].

Der Anaesthesist·2022
Same journal

[Anesthesia in patients with acute porphyria].

Der Anaesthesist·2022
Same journal

[Quality and safe anesthesia for all children : That is their right!]

Der Anaesthesist·2022
See all related articles

A new hypertonic saline hydroxyethyl starch (HS-HES) solution improved hemodynamics and reduced fluid needs in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). This volume therapy enhanced cardiac index and decreased systemic vascular resistance, with less compromise in pulmonary gas exchange.

Area of Science:

  • Anesthesiology
  • Cardiovascular Surgery
  • Critical Care Medicine

Background:

  • The optimal fluid for volume therapy in cardiac surgery remains debated.
  • Hypertonic sodium (HS) solutions are used for resuscitation in hemorrhagic shock.
  • The efficacy of a novel HS solution combined with hydroxyethyl starch (HES) in cardiac surgery warrants investigation.

Purpose of the Study:

  • To evaluate the hemodynamic effects and fluid management of a new hypertonic saline-hydroxyethyl starch (HS-HES) solution.
  • To compare HS-HES with a standard 6% HES solution and a control group during cardiac surgery.
  • To assess the impact on fluid balance, cardiac index (CI), systemic vascular resistance (SVR), and pulmonary gas exchange.

Main Methods:

  • A randomized controlled trial involving 90 patients undergoing aorto-coronary bypass grafting.

Related Experiment Videos

  • Patients were assigned to receive HS-HES, 6% HES, or no fluid infusion during three perioperative periods.
  • Hemodynamic parameters, fluid balance, and pulmonary gas exchange were monitored.

    • Main Results:

    • Significantly less HS-HES solution was required to increase pulmonary capillary wedge pressure (PCWP) compared to 6% HES.
    • The HS-HES group exhibited a negative fluid balance during cardiopulmonary bypass (CPB), unlike the other groups.
    • HS-HES administration led to increased CI, decreased SVR, and least compromised pulmonary gas exchange (paO2).

    Conclusions:

    • The HS-HES solution offers a novel approach to volume therapy in cardiac surgery.
    • It effectively improves hemodynamics with sustained effects on CI and SVR.
    • HS-HES significantly reduces fluid requirements and improves pulmonary function during and after CPB.