Serum trace element levels in HIV-infected subjects

Area of Science:

• Immunology
• Nutritional Science
• Clinical Chemistry

Background:

• Human Immunodeficiency Virus (HIV) infection is associated with various physiological changes.
• Trace element and mineral homeostasis can be affected by chronic infections.
• Understanding these alterations is crucial for managing HIV progression and patient health.

Purpose of the Study:

• To investigate serum mineral and trace element concentrations in HIV-infected men.
• To compare these levels with those in healthy controls.
• To explore correlations between specific minerals, trace elements, and T4 cell counts in HIV patients.

Main Methods:

• Serum samples were collected from 59 HIV-infected men (Walter-Reed staged) and healthy controls.
• Concentrations of Calcium (Ca), Copper (Cu), Iron (Fe), Potassium (K), Magnesium (Mg), Phosphorus (P), Selenium (Se), and Zinc (Zn) were measured.
• Statistical analyses were performed to compare groups and identify correlations.

Main Results:

• HIV-infected subjects showed significantly higher serum Ca, Cu, and Fe levels compared to controls.
• HIV-infected subjects had significantly lower serum P and Se levels.
• Absolute T4 cell count positively correlated with serum Mg concentration in HIV patients.

Conclusions:

• HIV infection significantly alters serum levels of key minerals and trace elements.
• Magnesium levels may serve as a potential indicator related to immune status (T4 cells) in HIV-infected individuals.
• Further research is warranted to explore the clinical implications of these mineral imbalances in HIV management.