Related Experiment Video
Updated: Jul 19, 2026

The Caco-2 Cell Bioassay for Measurement of Food Iron Bioavailability
Published on: April 28, 2022
Absence of an interaction between iron and mycophenolate mofetil absorption
Patricia Sanwald Ducray1, Ludger Banken, Marianne Gerber
1Clinical Pharmacology Department, F. Hoffmann-La Roche Ltd, Basel, Switzerland. patricia.sanwald_ducray@roche.com
Aim:
To determine whether concomitant iron affects the absorption of mycophenolate mofetil.
Methods:
An open-label, single centre, randomized, crossover trial was conducted in 16 healthy males. Fasting subjects received mycophenolate mofetil alone (treatment A) or co-administered with iron (treatment B).
Results:
The mycophenolic acid AUC(0,24 h) for treatments A and B were 42.5 +/- 10.5 and 44.7 +/- 12.4 microg ml(-1) h, respectively. anova modelling showed the relative bioavailability of mycophenolate mofetil to be similar for the two treatments (90% confidence interval 0.92, 1.19).
Conclusions:
There was no interaction between mycophenolate mofetil and iron supplements administered concomitantly to healthy fasting subjects.
Related Concept Videos
Factors Influencing Drug Absorption: Disease States and Pharmacology
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Drug Absorption: Factors Affecting GI Absorption
In...
Factors Influencing Drug Absorption: Presystemic Elimination
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
