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Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid
M Jibson1, K F Faull, J G Csernansky
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA.
Biological Psychiatry
|October 1, 1990
Abstract:
Intercorrelations among homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-hydroxy-phenylglycol (MHPG) concentrations in lumbar cerebrospinal fluid (CSF) were examined before and after blockade of the acid transport system by probenecid in 59 psychiatric inpatients. The three compounds remained intercorrelated despite acid transport blockade, suggesting that the common transport system does not account for their covariance. Other possibilities to explain the interrelationship among these compounds are discussed.