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Published on: January 17, 2014
Human antibody response towards the pneumococcal surface proteins PspA and PspC during invasive pneumococcal
Adam Linder1, Susan Hollingshead, Robert Janulczyk
1Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, SE-221 85 Lund, Sweden.
Abstract:
IgG antibodies against pneumococcal surface protein A, family 1 (PspA1) and family 2 (PspA2), protein C (PspC), and protein Hic were investigated in 41 patients with invasive pneumococcal disease. Pre-existing antibody levels against the four pneumococcal proteins were not significantly different from those found in 40 patients with non-pneumococcal bacteremia or 80 healthy controls. However, during convalescense a strong immune response developed especially against PspA, and there was a high degree of cross-reactivity between PspA- and PspC-antibodies. Our findings on immunogenicity and cross-reactivity suggest that in a future pneumococcal protein based vaccine, only a limited number of proteins could be sufficient.
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