Related Experiment Video
Updated: Jul 19, 2026

A Freeze-Thawing Method to Prepare Chitosan-Poly(vinyl alcohol) Hydrogels Without Crosslinking Agents and Diflunisal Release Studies
Published on: January 14, 2020
Characterization of chondroitin sulfate and its interpenetrating polymer network hydrogels for sustained-drug release
Shiu-Chih Wang1, Bing-Hung Chen, Li-Fang Wang
1College of Life Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung 807, Taiwan, ROC.
Abstract:
The goal of this work was to utilize the chondroitin sulfate (CS) based hydrogels for a drug delivery matrix. CS is a good structure/disease-modifying anti-osteroarthritis drug (S/DMOAD). However, the readily water-soluble nature limits its application as a solid-state drug-delivery vehicle. In this study, two methods were used to prepare CS hydrogels: directly crosslinking CS with poly(ethylene glycol) diglycidyl ether (EX-810) abbreviated as CS-EX or forming an interpenetrating polymer network named CS-EX-IPN. The CS-EX-IPN hydrogel was carried out by sequentially crosslinking reaction between CS and EX-810 in one phase and acrylic acid and di(ethylene glycol) diacrylate (DEGDA) as a counter phase. The swelling percent, cross-section morphology, and effective crosslinking density of hydrogels were characterized. The values of compression modulus and effective crosslinking density of CS-EX-IPN were approximately 3.6-fold higher than CS-EX. We also characterized the release of a model drug, diclofenac sodium (DS) and a model protein, bovine serum albumin (BSA), from CS-EX and CS-EX-IPN. The similar release profiles of DS were observed in the both hydrogels but slower release rate of BSA occurred in CS-EX-IPN. The release profiles of the two model drugs fit in a diffusion-controlled mechanism. The D(eff) values are in the order of 10(-5) for DS and 10(-7) for BSA.
More Related Videos
09:39Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
12:22Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Related Concept Videos
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Modified-Release Drug Delivery Systems: Rate-Programmed II
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Modified-Release Drug Delivery Systems: Stimuli-Activated
Oral Drug Delivery Systems: Delayed-Release Systems