Related Experiment Video
Updated: Jul 19, 2026

Measurement of Total Calcium in Neurons by Electron Probe X-ray Microanalysis
Published on: November 20, 2013
Thioperamide reduces intracellular calcium in mouse brain synaptosomes
Divya Vohora1, Shanthi N Pal, K K Pillai
1Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. divyavohora@hotmail.com
Abstract:
Intracellular calcium regulation is vital for cells, especially for neurons; raised levels are associated with cytotoxicity and neuronal death. In this report, we present the first experimental evidence showing a concentration-dependent reduction of free calcium in the mouse brain synaptosomes by thioperamide (THP), an H3 receptor antagonist. This is interesting in view of the recent reports on the anticonvulsant and cognition facilitating effects of THP. A neuroprotective potential of THP is suggested.

