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Updated: Jul 19, 2026

Surgical Management of Meatal Stenosis with Meatoplasty

Surgical Management of Meatal Stenosis with Meatoplasty

Published on: November 30, 2010

Human papillomavirus and circumcision: a meta-analysis.

Robert S Van Howe¹

¹Department of Pediatrics, Michigan State University College of Human Medicine, 1414 W. Fair Avenue, Suite 226, Marquette, MI 49855, USA. rsvanhowe@mgh.org

The Journal of Infection

|September 26, 2006

Summary

Circumcision status does not significantly impact the risk of genital human papillomavirus (HPV) infection. Further research emphasizes the need to sample the penile shaft for accurate HPV risk assessment in males.

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Area of Science:

Urology
Infectious Diseases
Public Health

Background:

Genital human papillomavirus (HPV) infections are a significant public health concern.
The role of male circumcision in preventing HPV acquisition remains a subject of investigation.

Purpose of the Study:

To determine the relationship between circumcision status and the risk of genital HPV infection.
To synthesize existing evidence through a meta-analysis.

Main Methods:

A comprehensive literature search of MEDLINE and Index Medicus was conducted.
Inclusion criteria required accurate HPV diagnosis (culture, biopsy, PCR) and circumcision status determination.
Meta-analysis and meta-regression were employed to analyze data from eligible studies.

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Last Updated: Jul 19, 2026

Surgical Management of Meatal Stenosis with Meatoplasty

Surgical Management of Meatal Stenosis with Meatoplasty

Published on: November 30, 2010

Main Results:

Sixteen articles were initially identified, with only three meeting strict inclusion criteria.
No significant association was found between circumcision status and HPV infection in the three high-quality studies (OR=1.20, 95% CI=0.80-1.79).
Meta-regression adjusting for diagnostic accuracy and sampling sites suggested a similar lack of association (OR=1.25, 95% CI=0.95-1.67).

Conclusions:

Current medical literature does not support the hypothesis that male circumcision reduces the risk of genital HPV infection.
Accurate assessment of HPV risk in circumcised males necessitates sampling of the penile shaft.