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Updated: Aug 15, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

Pituitary melanocorticotrophinoma with amyloid deposition

J M Bilbao, K Kovacs, E Horvath

    The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
    |August 1, 1975
    PubMed

    Insights

    This study reports on a pituitary adenoma containing ACTH and MSH cells and perivascular amyloid. The amyloid, identified as APUDamyloid, suggests cell origin influences amyloid structure in pituitary tumors.

    Area of Science:

    • Endocrinology
    • Pathology
    • Cell Biology

    Background:

    • Pituitary adenomas are common tumors affecting hormone production.
    • Amyloid deposition can occur in various tissues, including the pituitary.

    Observation:

    • A specific pituitary adenoma exhibited both adrenocorticotrophic hormone (ACTH) and melanocyte stimulating hormone (MSH) producing cells.
    • Light and electron microscopy revealed amyloid material deposited in the perivascular spaces within the adenoma.

    Findings:

    • Histochemical and fine structural analysis confirmed the perivascular material as APUDamyloid.
    • The amyloid was located in the extra-cellular perivascular spaces, distinct from the tumor cells.

    Implications:

    • This finding contributes to understanding the heterogeneity of pituitary adenomas.
    • The cell of origin may dictate the specific fine structure and distribution of amyloid in pituitary adenomas.
    • Further research into APUDamyloid in pituitary tumors could reveal new diagnostic or therapeutic targets.

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