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Updated: Jul 19, 2026

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
Published on: January 19, 2019
Mechanisms of seizure propagation in a cortical model
Mark A Kramer1, Andrew J Szeri, James W Sleigh
1Applied Science and Technology Graduate Group, University of California, Berkeley, CA 94720-1740, USA.
Abstract:
We consider a mathematical model of mesoscopic human cortical ictal electrical activity. We compare the model results with ictal electrocortical data recorded from three human subjects and show how the two agree. We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations. We compare the model results with the disinhibition and 4-AP models of epilepsy and suggest how the model may guide the development of new anticonvulsant therapies.
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