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Platelet-Rich Plasma Lysate for Treatment of Eye Surface Diseases
Published on: August 2, 2022
Platelet-rich plasma in endoscopic sinus surgery
1Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA. dhrice@usc.edu
Ear, Nose, & Throat Journal
|September 27, 2006
Summary
Platelet-rich plasma (PRP) showed no benefit in healing after endoscopic sinus surgery for chronic rhinosinusitis. Both PRP-treated and control sides healed quickly and without complications, indicating no added advantage.
Area of Science:
- Otolaryngology
- Regenerative Medicine
Background:
- Chronic rhinosinusitis (CRS) is a prevalent condition impacting quality of life.
- Medical management for CRS is often insufficient, necessitating surgical intervention.
- Endoscopic sinus surgery (ESS) is a common treatment for refractory CRS.
Purpose of the Study:
- To evaluate the efficacy of platelet-rich plasma (PRP) in enhancing post-operative healing following ESS.
- To compare healing outcomes between PRP-treated and standard treatment sides in patients undergoing bilateral ESS for CRS.
Main Methods:
- A prospective study involving 30 patients with bilateral, symmetrical CRS refractory to medical management.
- Randomized application of PRP to one middle meatus during ESS, with the contralateral side serving as a control.
- Clinical follow-up until complete bilateral healing was achieved.
Main Results:
- Early termination of the study after 13 operations due to lack of observed benefit from PRP.
- No significant difference in healing times or complication rates between PRP-treated and control sides.
- Both surgical sites demonstrated rapid and uneventful healing as expected.
Conclusions:
- Platelet-rich plasma (PRP) does not appear to offer any advantage in promoting healing after endoscopic sinus surgery for chronic rhinosinusitis.
- Standard post-operative care following ESS is effective for achieving satisfactory healing outcomes.
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